What symptom may indicate a patient is experiencing fluid depletion due to Addison's disease?

In Addison's disease, the adrenal glands do not produce sufficient amounts of cortisol and, in some cases, aldosterone. Aldosterone is crucial for regulating sodium and fluid balance in the body. When levels of cortisol are low, the body is unable to retain adequate sodium and therefore water, leading to a state of fluid depletion.

Nausea and vomiting are common symptoms in individuals experiencing adrenal crisis or significant fluid depletion due to Addison's disease. This is largely due to the body’s response to the stress of low fluid volume and potential electrolyte imbalances, prompting symptoms such as gastrointestinal upset. Therefore, the presence of nausea and vomiting in a patient with suspected Addison's disease can be a significant indicator of fluid depletion.

In contrast, other symptoms like weight gain and edema generally suggest fluid retention rather than depletion. Frequent urination could also be more indicative of other conditions rather than being a direct result of Addison's disease, especially when considering the overall context of fluid regulation and electrolyte balance in this endocrine disorder.