What is the mechanism of action for Indomethacin?

Indomethacin primarily acts as a prostaglandin synthetase inhibitor, which is the correct mechanism of action. Prostaglandins are lipid compounds that perform a variety of functions in the body, including promoting inflammation, pain, and fever. By inhibiting the enzyme responsible for their synthesis, indomethacin reduces the production of prostaglandins, thereby alleviating pain and inflammation. This action is particularly relevant in conditions such as arthritis and other inflammatory disorders.

In addition to its anti-inflammatory properties, indomethacin is sometimes used in obstetrics to help close a patent ductus arteriosus in premature infants due to its ability to decrease prostaglandins, which are also involved in maintaining the ductus arteriosus open. Understanding this mechanism helps contextualize its therapeutic uses and potential side effects associated with prostaglandin inhibition.