What is the first-line medication for treating hyperemesis gravidarum?

The first-line medication for treating hyperemesis gravidarum is Vitamin B6, also known as pyridoxine. This is a vitamin that plays a crucial role in the metabolism of proteins, fats, and carbohydrates, and it has been shown to help mitigate nausea in pregnant women. In cases of hyperemesis gravidarum, which is characterized by severe nausea and vomiting during pregnancy, Vitamin B6 can be used as a safe and effective initial treatment.

While ondansetron is often used for nausea, particularly in post-operative and chemotherapy settings, it is not typically the first choice for hyperemesis gravidarum due to potential concerns about its safety profile during pregnancy. Doxylamine is another option that, in combination with Vitamin B6, can be effective but is not considered the first-line single therapy. Metoclopramide can also be used to treat nausea, but it tends to be considered when other treatments have failed.

In summary, Vitamin B6 is generally recommended as the first-line treatment due to its safety, effectiveness, and the clinical guidelines supporting its use in the management of hyperemesis gravidarum during pregnancy.