What BUN level would indicate an adverse effect in a client receiving tobramycin for osteomyelitis?

A BUN level of 30 mg/dL could indicate an adverse effect in a client receiving tobramycin, particularly concerning the risk of nephrotoxicity associated with aminoglycosides like tobramycin. Normal BUN levels typically range from 7 to 20 mg/dL. When levels rise above this range, especially significantly, it may suggest impaired kidney function or dehydration, both of which can be exacerbated by the use of nephrotoxic medications.

In the context of ongoing treatment for osteomyelitis, monitoring renal function is vital since tobramycin can cause damage to the renal tubules. A BUN level of 30 mg/dL indicates a potential concern, warranting further assessment of the patient's renal function and hydration status. Such an elevation would prompt clinicians to consider adjusting the dosage, hydration protocols, or alternative treatments to prevent further renal impairment while effectively managing the infection.