If resistance is met while flushing a PICC line, what should a nurse do?

When resistance is encountered while flushing a PICC line, stopping the procedure and notifying the physician is the appropriate action. This response is critical because resistance can indicate a potential complication, such as a blockage, thrombus formation, or catheter malposition. Applying increased force to the syringe or continuing to flush without addressing the issue could damage the catheter, cause it to dislodge, or lead to serious patient complications, such as embolism. Leveraging the syringe to try to manipulate the angle could also exacerbate the problem and compromise the integrity of the line. Therefore, the prudent action is to halt any further attempts and consult with the physician for a proper assessment and intervention. Recognizing and addressing resistance appropriately ensures the safety and well-being of the patient.